Problem: Calvinist interpreters understand this to refer to irresistible grace: that is, if the Father gives someone to the Son, then he will bring them to eternal life. The logic of their position is as follows:
(1) All that the Father gives to Jesus will definitely come to Jesus (v.37).
(2) If the Father gives people to Jesus, then Jesus will definitely raise them up on the last day (v.39). This resurrection must refer to eternal life.
(3) Therefore, if the Father gives someone (and not another), they will definitely get eternal life.