Problem: Jesus commanded His followers to “make disciples of all the nations” (Matt. 28:19) and to be witnesses to “the end of the earth” (Acts 1:8). But in Acts 16 Paul and Timothy “were forbidden by the Holy Spirit to preach the word in Asia” (v. 6).
Solution: Paul was only forbidden immediately. God had a more strategic route for the Gospel through Europe first (Acts 16:9). Eventually, however, the Gospel got to Asia and to every place through Paul’s converts in Europe (cf. 1 Thes. 1:7) and by Paul himself (Acts 19:10, 22, 26; 20:4, 16, 18; 1 Cor. 16:19). So, the prohibition was only temporary, not permanent.
“Now when they had gone throughout Phrygia and the region of Galatia, and were forbidden of the Holy Ghost to preach the word in Asia, (Acts 16:6)”